凋亡通路磷酸化抗体芯片
凋亡通路磷酸化抗体芯片
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凋亡通路磷酸化抗体芯片

     细胞凋亡（apoptosis）指为维持内环境稳定，由基因控制的细胞自主的有序的死亡。细胞凋亡与细胞坏死不同，细胞凋亡不是一件被动的过程，而是主动过程，它涉及一系列基因的激活、表达以及调控等的作用，它并不是病理条件下，自体损伤的一种现象，而是为更好地适应生存环境而主动争取的一种死亡过程。


产品目录


种类货号检测指标载体
人凋亡信号通路磷酸化抗体芯片AAH-APOSIG-119膜
小鼠凋亡信号通路磷酸化抗体芯片AAM-APOSIG-117膜
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AAH-APOSIG-1

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Target Names


Akt (P-Ser473)
(PKB (P-Ser473))

ATM (P-Ser1981)

BAD (P-Ser112)

Caspase-3 (Cleaved Asp175)

Caspase-7 (Cleaved Asp198)

CHK1 (P-Ser296)

CHK2 (P-Thr68)

eIF-2a (P-Ser52)

ERK1 (P-T202/Y204)/ERK2 (P-Y185/Y187)

HSP27 (P-Ser82)

IKBa (P-Ser32)

JNK (P-Thr183/Tyr185)

NFKBP65 (P-Ser536)

PARP1 (Cleaved Asp214/Gly215)

p27 (P-Thr198)

P53 (P-Ser15)

SMAD2 (Ser245/250/255)

TAK1 (P-Ser412)





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AAM-APOSIG-1

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Target Names



AKT (P-Ser473)

ATM (P-Ser1981)

BAD (P-Ser112)

Caspase-3 (P-Asp175)

Caspase-7 (P-Asp198)

CHK1 (P-Ser296)

eIF-2a (P-Ser52)

ERK1/2 (P-Thr202)

HSP27 (P-Ser82)

IKBa (P-Ser32)

JNK (P-Thr183)

NF-kB P65 (P-Ser536)

p27 (P-Thr198)

p38 (P-Thr180/Tyr182)

P53 (P-Ser15)

SMAD2 (P-Ser245)

TAK1 (P-Ser412)







Citations


  1. Bao X, Shi J, Xie F, et al. Proteolytic Release of the p75NTR Intracellular Domain by ADAM10 Promotes Metastasis and Resistance to Anoikis. Cancer Res. 2018;78(9):2262-2276. doi:10.1158/0008-5472.CAN-17-2789
    Species: Human
    Sample type: Cell Lysate (carcinoma cells)

  2. Vergani E, Dugo M, Cossa M, Frigerio S, Di Guardo L, Gallino G, Mattavelli I, Vergani B, Lalli L, Tamborini E, Valeri B, Gargiuli C, Shahaj E, Ferrarini M, Ferrero E, Gomez Lira M, Huber V, Vecchio MD, Sensi M, Leone BE, Santinami M, Rivoltini L, Rodolfo M, Vallacchi V. miR-146a-5p impairs melanoma resistance to kinase inhibitors by targeting COX2 and regulating NFkB-mediated inflammatory mediators. Cell Commun Signal. 2020 Sep 23;18(1):156. doi: 10.1186/s12964-020-00601-1. PMID: 32967672; PMCID: PMC7510138.
    Species: Human
    Sample type: Cell Lysate

  3. Hii, LW., Lim, SH.E., Leong, CO. et al. The synergism of Clinacanthus nutans Lindau extracts with gemcitabine: downregulation of anti-apoptotic markers in squamous pancreatic ductal adenocarcinoma. BMC Complement Altern Med 19, 257 (2019). https://doi.org/10.1186/s12906-019-2663-9
    Species: Human
    Sample type: Conditioned Media (cell culture media)

  4. Smolensky D, Rhodes D, McVey DS, et al. High-Polyphenol Sorghum Bran Extract Inhibits Cancer Cell Growth Through ROS Induction, Cell Cycle Arrest, and Apoptosis. J Med Food. 2018;21(10):990-998. doi:10.1089/jmf.2018.0008
    Species: Human
    Sample type: Cell Lysate (liver heptaocellular carcinoma)

货号
AAH-APOSIG
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