数据库|《Nculeic Acids Research》发表预测功能性microRNA靶标的在线数据库miRDB

miRDB:   an online database for prediction of functional microRNA targets11.147Nucleic Acids Res . 2020 Jan 8;48(D1):D127-D131. doi: 10.1093/nar/gkz757.

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that act as master regulators in many biological processes. miRNAs function mainly by downregulating the expression of their gene targets. Thus, accurate prediction of miRNA targets is critical for characterization of miRNA functions. To this end, we have developed an online database, miRDB, for miRNA target prediction and functional annotations. Recently, we have performed major updates for miRDB. Specifically, by employing an improved algorithm for miRNA target prediction, we now present updated transcriptome-wide target prediction data in miRDB, including 3.5 million predicted targets regulated by 7000 miRNAs in five species. Further, we have implemented the new prediction algorithm into a web server, allowing custom target prediction with user-provided sequences. Another new database feature is the prediction of cell-specific miRNA targets. miRDB now hosts the expression profiles of over 1000 cell lines and presents target prediction data that are tailored for specific cell models. At last, a new web query interface has been added to miRDB for prediction of miRNA functions by integrative analysis of target prediction and Gene Ontology data. All data in miRDB are freely accessible at http://mirdb.org.

2019年8月，《Nucleic Acids Research》发表了题为《miRDB:   an online database for prediction of functional microRNA targets》的文章，介绍了能够预测microRNA靶标及功能的在线数据库miRDB。

miRNA即小的非编码RNA，在许多生物学过程中都起着主要调节器的作用。miRNA的功能主要是通过下调其基因靶标的表达来实现的。因此，准确预测miRNA靶标对于表征miRNA功能至关重要。

miRDB（http://mirdb.org）主要用于miRNA靶标的预测和功能注释，提供了最新的转录组范围靶标预测数据，包括5个物种的7000个miRNA调控的350万个预测靶标。数据库特有的预测算法，可以对用户提供的序列进行自定义目标预测。此外，该数据库容纳了1000多种细胞系的表达谱，可以预测细胞特异性miRNA目标。这些功能有助于研究人员快速识别特定试验系统中相关miRNA，便于在各种实验环境中灵活分析miRNA功能。