精选文献推荐

01

Benchmarking of alignment-free sequence comparison methods



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doi: https://doi.org/10.1101/611137


关键点

alignment-free (AF) 相关的工具及如何评价。


         

02

Bazam: a rapid method for read extraction and realignment of high-throughput sequencing data



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https://doi.org/10.1186/s13059-019-1688-1


关键点

bam 文件似乎可以方便的回滚了



03

Antisense lncRNA Transcription Mediates DNA Demethylation to Drive Stochastic Protocadherin α Promoter Choice



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https://doi.org/10.1016/j.cell.2019.03.008


关键点

反义 lncRNA 转录可以影响DNA甲基化，进而改变染色体结构促进增强子与启动子结合，调控基因表达。

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04

exceRpt: A Comprehensive Analytic Platform for Extracellular RNA Profiling



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https://doi.org/10.1016/j.cels.2019.03.004


关键点

一套分析 exRNA 的完整方案


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