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做肿瘤研究的过程中，生存分析是一个很常见的研究分析，研究者可以根据生存分析的结果判断某个因素，比如基因表达，对患者预后生存的影响。
TCGA这个肿瘤研究的宝库包含了多个肿瘤Cancer Types Index的生存数据，一直以来都是数据挖掘的宝库。
我们本次收集了大家广泛研究的基因集（GeneSet），分析这些基因在TCGA的不同肿瘤类型中与病人生存期的关系。每个基因集分别进行基因表达与生存数据的Cox回归分析、KM生存分析、风险指数建模以及与病人多个临床因素的关联等分析。
本分析花费6天6夜给大家带来丰富内容：
结果按照基因集和肿瘤类型组合分别存储为独立数据包，可供选择。另外也接受基因集私人定制。
两百多个与肿瘤相关的GeneSet分别在TCGA的33种肿瘤中进行分析，GeneSet使用的为GSEA的。
| H: hallmark gene sets (browse 50 gene sets) | We envision this collection as the starting point for your exploration of the MSigDB resource and GSEA. Hallmark gene sets summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying gene set overlaps and retaining genes that display coordinate expression. The hallmarks reduce noise and redundancy and provide a better delineated biological space for GSEA. We refer to the original overlapping gene sets, from which a hallmark is derived, as its 'founder' sets. Hallmark gene set pages provide links to the corresponding founder sets for deeper follow up. This collection is an initial release of 50 hallmarks which condense information from over 4,000 original overlapping gene sets from v4.0 MSigDB collections C1 through C6. We refer to the original gene sets as "founder" sets. Hallmark gene set pages provide links to the corresponding founder sets for more in-depth exploration. In addition, hallmark gene set pages include links to microarray data that served for refining and validation of the hallmark signatures. To cite your use of the collection, and for further information, please refer to The Molecular Signatures Database (MSigDB) hallmark gene setcollection.Cell Syst.2015 Dec 23;1(6):417-425. |
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| C6: oncogenic signatures (browse 189 gene sets) | Gene sets represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments which involved perturbation of known cancer genes. In addition, a small number of oncogenic signatures were curated from scientific publications. To cite your use of the collection, and for further information, please refer to Emerging landscape of oncogenic signatures across humancancers. Nat Genet. 2013Oct;45(10):1127-33. doi: 10.1038/ng.2762. Oncogenic pathway signatures in human cancers asa guide to targeted therapies. Nature. 2006 Jan 19;439(7074):353-7.Epub 2005 Nov 6. |
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