NULISA文献汇总

所用技术作者合作单位区域文章标题发表期刊影响因子中科院分区发表年份发表月份研究内容样本种属样本类型疾病类型科室解读链接
NULISAseqNancy Y IpThe Hong Kong University of Science and Technology香港Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathologyProc Natl Acad Sci U S A9.11区20263港科大头对头比较脑源性BD-pTau217和总pTau217的AD血液检测性能人血浆阿尔茨海默病神经内科https://mp.weixin.qq.com/s/njJacr2JGr7df_MKVFMQjQ
NULISAseqNancy Y IpThe Hong Kong University of Science and Technology香港The TREM2 H157Y variant is associated with more severeneurodegeneration in Alzheimer's disease and altered immune-related processesAlzheimers Dement131区2025
9【中国声音】港科大率先借助NULISA技术研究TREM2遗传变体对神经退行性病变及炎症相关蛋白的影响人血浆阿尔茨海默病神经内科https://mp.weixin.qq.com/s/dEMLImig4b9JqL1zvVTLqA
NULISAseqMitchell LaiNational University of Singapore新加坡Plasma brain-derived p-tau217 outperforms other p-tau species in detecting abnormal brain amyloid in an Asian cohort of older people with cerebrovascular disease burdenmedRxiv

    2025
12NULISA™技术特异性检测三种 “血浆脑源性 pTau”及总pTau人血浆阿尔茨海默病神经内科https://mp.weixin.qq.com/s/HYMjnzKpUFNGhwrMWFy1HA
NULISAseqKatherine GongWashington University School of Medicine美国High-sensitivity plasma proteomics reveals disease-specific signatures and predictive biomarkers of Alzheimer’s disease phenotypes in a large mixed-dementia cohortMolecular Neurodegeneration14.91区2025
11
【鉴别诊断】WashU借助NULISA揭示神经退行性疾病特异性标志物与预测生物标志物人血浆阿尔茨海默病AD、帕金森病PD、路易体痴呆DLB、额颞叶痴呆患者FTD神经内科https://mp.weixin.qq.com/s/XFEB69KNBtVq722HfrhS3Q
NULISAseqJames Doacke

Australian E-Health Research Centre (CSIRO)

AbbVie

澳大利亚

Multivariate models using NULISAseq and plasma p-tau217 for

staging Alzheimer’s disease

Alzheimer’s & Dementia11.11区202510p-tau217 联手 370 种蛋白，把阿尔茨海默疾病分成五期人血浆阿尔茨海默病神经内科https://mp.weixin.qq.com/s/WiJtxbr1FKrpBzP742vRiw
NULISAseqSuzanne CraftWake Forest University School of Medicine美国A phase 2A/B randomized trial of metabolic modulatorsintranasal insulin and empagliflozin for MCI and early ADAlzheimer's & Dementia11.11区2025
7一项2A/B期随机试验的代谢调节剂鼻内胰岛素和恩格列净用于MCI和早期AD人脑脊液+血液阿尔茨海默病神经内科https://mp.weixin.qq.com/s/acuAI3AtAIkTZJ1MTZu0pg
NULISAseqAnuradha SehrawatUniversity of Pittsburgh美国Pittsburgh plasma p-tau217: Classification accuracies for autosomal dominant and sporadic Alzheimer's disease in the communityAlzheimer's & Dementia11.11区20257匹兹堡血浆p-tau217：社区中常染色体显性和散发性阿尔茨海默病人血浆阿尔茨海默病神经内科https://mp.weixin.qq.com/s/QupOzw0kfpihlRlI5lfPvw
NULISAseqHasim GezegenUCL Institute of Neurology英国Unravelling the plasma proteome: Pioneering biomarkers for differential dementia diagnosisAlzheimer's & Dementia11.11区20257借助NULISA 鉴别诊断阿尔茨海默病、路易体痴呆与额颞叶痴呆人人阿尔茨海默病、路易体痴呆与额颞叶痴呆神经内科https://mp.weixin.qq.com/s/yXQziuLx9IExfMur3eVPcw
NULISAseqTracy L. Young-PearseBrigham and Women's Hospital美国CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia dependent synaptic densityNeuron151区20256哈佛医学院：借助NULISA揭示聚集素CLU可缓解与阿尔茨海默病相关的病理过程人血浆阿尔茨海默病、路易体痴呆与额颞叶痴呆神经内科https://mp.weixin.qq.com/s/sb7vs5XlsP_OBvmITJNEgA
NULISAseqHenrik Zetterberg and Nick AshtonUniversity of Gothenburg瑞典Biomarker Discovery in Alzheimer’s and Neurodegenerative Diseases using Nucleic Acid-Linked Immuno-Sandwich AssayAlzheimer’s & Dementia11.11区20255Alzheimer's & Dementia：哥德堡大学借助NULISA探索阿尔茨海默病及神经退行性疾病的生物标志物人血浆、血清、脑脊液阿尔茨海默病神经内科https://mp.weixin.qq.com/s/EegkEONlQsscZCQepH3G2g
NULISAseqCarlos CruchagaWashington University, St. Louis美国Large-scale plasma proteomic profiling unveils diagnostic biomarkers and pathways for Alzheimer’s diseaseNature Aging19.51区20255Nature Aging（一区 IF=19.5）大规模血浆蛋白质组学分析揭示阿尔茨海默病的诊断生物标志物及相关通路人血浆阿尔茨海默病神经内科https://mp.weixin.qq.com/s/9W2ACy_JdL-z9YFw6hI98A
NULISAseqSterling C. JohnsonUW Madison美国Targeted Proteomic Biomarker Profiling Using NULISA in a cohort enriched with risk for Alzheimer's Disease and Related DementiasAlzheimer’s & Dementia11.11区20255借助NULISA提示pTDP43-409为轻度认知障碍MCI潜在标志物人252 份横断面血浆样本阿尔茨海默病神经内科https://mp.weixin.qq.com/s/fO_2lihprbuLxqidK_EF6A
NULISAseqRobert DurcanUniversity of Cambridge and Cambridge University Hospitals NHS Trust英国Novel blood-based proteomic signatures across multiple neurodegenerative diseasesAlzheimer’s & Dementia11.11区20255【鉴别诊断】剑桥大学等借助NULISA对阿尔茨海默病、路易体痴呆、额颞叶痴呆、进行性核上性麻痹的鉴别诊断探索人血清阿尔茨海默病（AD）、路易体痴呆（LBD）、额颞叶痴呆（FTD）、进行性核上性麻痹（PSP）神经内科https://mp.weixin.qq.com/s/riBvlc8dfOP0TCKYVSW8Tw
NULISAseqMarc Suárez-CalvetBarcelonaBeta BRC西班牙A head-to-head comparison of plasma biomarkers to detect biologically defined Alzheimer in a memory clinicAlzheimer’s & Dementia11.11区20252NULISA技术用于阿尔茨海默病（AD）研究和转化人血浆阿尔茨海默病神经内科https://mp.weixin.qq.com/s/gD0kS5WVefkfyMwI-LKVLg
NULISAseqAnna DittrichUniversity of Gothenburg瑞典Evaluation of two plasma-based proteotyping assays against APOE ε4 genotyping in a memory clinic setting: The Gothenburg H70 Clinical StudiesAlzheimer’s & Dementia11.11区20252NULISA技术用于阿尔茨海默病（AD）研究和转化人血浆阿尔茨海默病神经内科https://mp.weixin.qq.com/s/q97WhAkJYCu5Z5Sdw1WD0A
NULISAseqThomas K. KarikariUniversity of Pittsburgh美国Novel plasma biomarkers of amyloid plaque pathology and cortical thickness: evaluation of the NULISA targeted proteomic platform in an ethnically diverse cohortAlzheimer’s & Dementia11.11区20252NULISA技术用于阿尔茨海默病（AD）研究和转化人血浆阿尔茨海默病神经内科https://mp.weixin.qq.com/s/gD0kS5WVefkfyMwI-LKVLg
NULISAseqNick Ashton and Henrik ZetterbergUniversity of Gothenburg瑞典The Alzheimer’s Association Global Biomarker Standardization Consortium (GBSC) plasma phospho-tau Round Robin studyAlzheimer’s & Dementia11.11区20252NULISA技术用于阿尔茨海默病（AD）研究和转化人血浆阿尔茨海默病神经内科https://mp.weixin.qq.com/s/gD0kS5WVefkfyMwI-LKVLg
NULISAseqGuglielmo Di MolfettaUniversity of Gothenburg瑞典Inflammation biomarkers and Alzheimer's disease: A pilot study using NULISAseqMolecular Neurodegeneration14.91区20251哥德堡大学：首次采用NULISAseq炎症Panel对于阿尔茨海默病进行试点研究人血清阿尔茨海默病神经内科https://mp.weixin.qq.com/s/wAQFiDml799mFUwwrKL7_A
NULISAseqCarlos CruchagaWashington University, St. Louis美国Benchmarking of a multi-biomarker low-volume panel for Alzheimer’s disease and related dementia researchAlzheimer’s & Dementia11.11区202411NULISA从微量样本中一次性准确检测100多种阿尔茨海默病及相关疾病标志物人44例空腹CSF样本和44例非空腹血浆样本阿尔茨海默病神经内科https://mp.weixin.qq.com/s/OIQZnsGMnKOTNzB0XAfYUw
NULISAseqCarlos CruchagaWashington University, St. Louis美国CSF proteomics identifies early changes in autosomal dominant Alzheimer’s diseaseCell42.5
1区202410采用NULISA验证常染色体显性阿尔茨海默病的早期变化人脑脊液阿尔茨海默病神经内科https://mp.weixin.qq.com/s/lRUAaDRLRjz1_vV8gnjxXA


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